Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 7-Chloro-10-[(6-dimethylaminohexyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | 1-Aza-6,9-dichloro-2-methoxyacridine | HCID 23107 | — |
| 반응물 | 6-(Dimethylamino)hexylamine | HCID 258544 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 7-Chloro-10-[(6-dimethylaminohexyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride | HCID 23337814 | — |
반응 단계
A mixture of 2.8 g. of 7,10-dichloro-2-methoxypyrido [3,2-b]quinoline, 1.5 g. of dimethylaminohexylamine and 6.5 g. of phenol is stirred and heated on a steam bath for 3 hours. The mixture is cooled, 20 ml. of ethanol are added and the dark solution is poured into a mixture of 200 ml. of acetone and 2.5 ml. of concentrated hydrochloric acid. The mixture is cooled in ice. The solid is collected, air-dried and recrystallized from 3A alcohol:acetone (50:50), giving the desired product as yellow crystals, mp. 243°-244° C. (dec.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04226869 |
| 출처 데이터셋 | uspto-grants-1980_10 |
| ORD ID | ord-498878e22acd4646ad34eac2c127fbcc |
| 출처 메모 | uspto-grants-1980_10 |