反应详情

A mixture of 2.8 g. of 7,10-dichloro-2-methoxypyrido [3,2-b]quinoline, 1.5 g. of dimethylaminohexylamine and 6.5 g. of phenol is stirred and heated on a steam bath for 3 hours. The mixture is cooled, 20 ml. of ethanol are added and the dark solution is poured into a mixture of 200 ml. of acetone and 2.5 ml. of concentrated hydrochloric acid. The mixture is cooled in ice. The solid is collected, air-dried and recrystallized from 3A alcohol:acetone (50:50), giving the desired product as yellow crystals, mp. 243°-244° C. (dec.).

1. additionA mixture of 2.8 g
2. temperatureheated on a steam bath for 3 hours
3. temperatureThe mixture is cooled
4. additionthe dark solution is poured into a mixture of 200 ml
5. temperatureThe mixture is cooled in ice
6. customThe solid is collected
7. customair-dried
8. customrecrystallized from 3A alcohol:acetone (50:50)