Water → 2-[4'-(4"-Chlorophenoxy)phenoxy]-propionic acid 4-chlorobut-1-yl ester

HRID 903380노트

반응식

HRID 903380 반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C:7]2[CH:18]=[CH:17][C:10]([O:11][CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Cl:21][CH2:22][CH2:23][CH2:24][CH2:25]O.S(=O)(=O)(O)O.O>C(Cl)(Cl)Cl>[Cl:21][CH2:22][CH2:23][CH2:24][CH2:25][O:14][C:13](=[O:15])[CH:12]([O:11][C:10]1[CH:17]=[CH:18][C:7]([O:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:20][CH:19]=2)=[CH:8][CH:9]=1)[CH3:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 135694-Chloro-1-butanolHCID 64928Clofop

생성물 1

HCID 544272872-[4'-(4"-Chlorophenoxy)phenoxy]-propionic acid 4-chlorobut-1-yl ester

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

24.4 g=0.08 mol of 2-[4'-(4"-chlorophenoxy)phenoxy]-propionic acid, 10.8 g=0.1 mol of 4-chlorobutanol and 2 ml concentrated sulfuric acid in 50 ml chloroform were refluxed for 6 hours with azeotropic distillation of the reaction water. After cooling, the reaction mixture was washed twice with 100 ml water, neutralized with bicarbonate solution and washed with water until it was free from salt. After drying over calcium chloride and distillation of the solvent, 27.0 g=88% of the theory of 2-[4'-(4"-chlorophenoxy)phenoxy]-propionic acid 4-chlorobut-1-yl ester were obtained having a refractive index nD24 of 1.5517. ##STR16##

후처리

  1. temperatureAfter cooling
  2. washthe reaction mixture was washed twice with 100 ml water
  3. washwashed with water until it
  4. dry with materialAfter drying over calcium chloride and distillation of the solvent, 27.0 g=88% of the theory of 2-[4'-(4"-chlorophenoxy)phenoxy]-propionic acid 4-chlorobut-1-yl ester
  5. customwere obtained

출처 및 근거

ORD 기록
ord-9eea7b03f4744be98d8b812d6cfd0338
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04227009

반응 노트

불러오는 중…