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Hexamethylphosphoramide → 2,3-Dihydroxypropyl 4-(8-cyclohexyloctylamino)benzoate

HRID 903415
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HRID 903415 반응식
[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].I[CH2:28][CH:29]([OH:32])[CH2:30][OH:31].CN(C)P(N(C)C)(N(C)C)=O>O.CCOCC>[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([O:22][CH2:28][CH:29]([OH:32])[CH2:30][OH:31])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 12679HexamethylphosphoramideHCID 14798Sodium HydroxideHCID 921273-Iodo-1,2-propanediolHCID 204757724-(8-Cyclohexyloctylamino)benzoic acid

생성물 1

HCID 204758122,3-Dihydroxypropyl 4-(8-cyclohexyloctylamino)benzoate

시약·촉매·용매 2

HCID 962Water용매
HCID 3283Diethyl Ether용매

실험 절차

A solution of 7.34 g. of 4-(8-cyclohexyloctylamino)benzoic acid, 4.80 g. of 25% aqueous sodium hydroxide, and 12.6 g. of 3-iodo-1,2-propanediol in 50 ml. of hexamethylphosphoramide is stirred for 24 hours at ambient temperature, diluted with 100 ml. of ether and stirred for 5 days at ambient temperature. The mixture is treated with water and extracted with ether. The dried extracts are evaporated to yield the product.

후처리

  1. additiondiluted with 100 ml
  2. extractionextracted with ether
  3. customThe dried extracts are evaporated
  4. customto yield the product

출처 및 근거

ORD 기록
ord-4743a01f29bd4b1eb6f9dc921ea294ed
출처 데이터셋
uspto-grants-1980_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04227014

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