Sodium Hydroxide → N-[4-(8-cyclohexyloctylamino)benzoyl]glycine

HRID 903419노트

반응식

HRID 903419 반응식
[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:30]=[CH:29][C:19]([C:20]([NH:22][CH2:23][C:24]([O:26]CC)=[O:25])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:30]=[CH:29][C:19]([C:20]([NH:22][CH2:23][C:24]([OH:26])=[O:25])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20475823Ethyl 4-(8-cyclohexyloctylamino)hippurate

생성물 1

HCID 20475803N-[4-(8-cyclohexyloctylamino)benzoyl]glycine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 26.4 g. of ethyl N-[4-(8-cyclohexyloctylamino)benzoyl]glycinate, 110 ml. of 1 N sodium hydroxide solution; and 100 ml. of ethanol is stirred at ambient temperature for 2 hours and then partially evaporated. The aqueous solution is washed with diethyl ether, acidified with 6 N hydrochloric acid, and filtered. The white solid is dried in vacuo and recrystallized from acetone to yield the product.

후처리

  1. additionA mixture of 26.4 g
  2. custompartially evaporated
  3. washThe aqueous solution is washed with diethyl ether
  4. filtrationfiltered
  5. customThe white solid is dried in vacuo
  6. customrecrystallized from acetone
  7. customto yield the product

출처 및 근거

ORD 기록
ord-aabe78f552ce425bb304f78cd88e5380
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04227014

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