Dimethylamine → [(2-Chloro-6-fluoro-phenyl)-(1-methyl-1H-indol-3-yl)-methyl]-dimethyl-amine

HRID 9035

반응식

HRID 9035 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[Cl-].[Cl:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:14]=1[CH:15]=[N+:16]([CH3:18])[CH3:17].ClC1C=CC=C(F)C=1C=O.CNC>>[Cl:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:14]=1[CH:15]([N:16]([CH3:18])[CH3:17])[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:2]([CH3:1])[CH:3]=1

참가 물질

5

반응물 4

HCID 674DimethylamineHCID 117811-MethylindoleHCID 678472-Chloro-6-fluorobenzaldehydeHCID 21985312(2-Chloro-6-fluoro-benzylidene)-dimethylammonium chloride

생성물 1

HCID 21985297[(2-Chloro-6-fluoro-phenyl)-(1-methyl-1H-indol-3-yl)-methyl]-dimethyl-amine

실험 절차

The preparation was carried out in accordance with general synthesis instructions 4 from 1-methylindole and (2-chloro-6-fluoro-benzylidene)-dimethyl-ammonium chloride, which had been prepared in accordance with example 24 from 2-chloro-6-fluoro-benzaldehyde and dimethylamine.

출처 및 근거

ORD 기록
ord-a7345c951d05470292bcb46ef9aae0f4
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091220B2

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