Hydrochloric Acid → 7-Fluorosulfonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
반응식
FC(F)(F)C([N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([S:15]([F:18])(=[O:17])=[O:16])=[CH:10][CH:11]=2)[CH2:6]1)=O.[ClH:21]>CC(C)=O>[ClH:21].[F:18][S:15]([C:9]1[CH:8]=[C:7]2[C:12]([CH2:13][CH2:14][NH:5][CH2:6]2)=[CH:11][CH:10]=1)(=[O:16])=[O:17]참가 물질
4
실험 절차
A solution of 5.0 g. (0.06 mole) of 2-trifluoroacetyl-7-fluorosulfonyl-1,2,3,4-tetrahydroisoquinoline and 100 ml. of acetone and 50 ml. of 6 N hydrochloric acid was stirred at room temperature overnight. The solution was concentrated, taken up in water, extracted with chloroform, concentrated and the water azeotropically removed. The resultant solid was recrystallized from methanol to give 7-fluorosulfonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride, m.p. 230°-232° C.
후처리
- concentrationThe solution was concentrated
- extractionextracted with chloroform
- concentrationconcentrated
- customthe water azeotropically removed
- customThe resultant solid was recrystallized from methanol
출처 및 근거
- ORD 기록
- ord-c017c1a3a71e4b15b3a92f775cf983fd
- 출처 데이터셋
- uspto-grants-1980_10
- 특허 번호
- US04228170
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