Ethylenediamine → N-cyano-N'-ethyl-N"-[2-((4-methyl-5-oxazolyl)methylamino)ethyl]guanidine

HRID 903771노트

반응식

HRID 903771 반응식
ClC[C:3]1O[CH:6]=[N:5][C:4]=1C.[CH2:9]([NH2:12])CN.[CH3:13][C:14]1[N:15]=[CH:16][O:17][C:18]=1[CH2:19][NH:20][CH2:21][CH2:22][NH2:23].C([N:26]=C=S)C>>[C:9]([NH:12][C:6]([NH:5][CH2:4][CH3:3])=[N:23][CH2:22][CH2:21][NH:20][CH2:19][C:18]1[O:17][CH:16]=[N:15][C:14]=1[CH3:13])#[N:26]

참가 물질

5

반응물 4

HCID 3301EthylenediamineHCID 10966Ethyl isothiocyanateHCID 2054855-(Chloromethyl)-4-methyl-1,3-oxazoleHCID 14009880N-(4-methyl-5-oxazolylmethyl)ethylenediamine

생성물 1

HCID 57257796N-cyano-N'-ethyl-N"-[2-((4-methyl-5-oxazolyl)methylamino)ethyl]guanidine

실험 절차

Reacting of 5-chloromethyl-4-methyloxazole with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(4-methyl-5-oxazolylmethyl)ethylenediamine with ethyl isothiocyanate by the procedure of Example 3(b) gives, after purifying by column chromatography, N-ethyl-N'-[2-(4-methyl-5-oxazolylmethylamino)ethyl]thiourea. This thiourea is reacted with lead cyanamide by the procedure of Example 3(b) to give N-cyano-N'-ethyl-N"-[2-((4-methyl-5-oxazolyl)methylamino)ethyl]guanidine.

후처리

  1. customgives
  2. customafter purifying by column chromatography, N-ethyl-N'-[2-(4-methyl-5-oxazolylmethylamino)ethyl]thiourea
  3. customThis thiourea is reacted with lead cyanamide by the procedure of Example 3(b)

출처 및 근거

ORD 기록
ord-e6fbedde8c2348828aec408157ff95a2
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04228291

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