참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | creatinine | HCID 588 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 3-Isocyanatothiophene | HCID 2776380 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(Tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene)-3-(3-thienyl) urea | HCID 135997381 | — |
반응 단계
To a stirred suspension of 2.6 (23 mM) of creatinine in 50 ml of anhydrous DMF was added a solution of 3.0 g (23 mM) of 3-thienyl isocyanate in 25 ml of toluene. The resulting mixture was heated at 75° C. for 4.5 hrs., cooled and added to 150 ml of water. The resulting precipitate was collected and recrystallized from ethyl acetate to give 1.4 g of the above urea as a cream colored solid, m.p. 194°-195° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04230713 |
|---|
| 출처 데이터셋 | uspto-grants-1980_10 |
|---|
| ORD ID | ord-f71dccdbae0b4d73ae5916391199af33 |
|---|
| 출처 메모 | uspto-grants-1980_10 |
|---|
