Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]urea

반응식

[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:15]

참가 물질

반응물 2

HCID 12228Methyl Isocyanate

HCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

생성물 1

HCID 20557658N-Methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]urea

실험 절차

By the procedure of Example 24, N-(2-pyrimidylmethyl)ethylenediamine is reacted with methyl isocyanate to give, after concentrating and separating the residue by column chromatography, the title compound.

후처리

customto give
concentrationafter concentrating
customseparating the residue by column chromatography

출처 및 근거

ORD 기록: ord-bde4b8c325d041cb86138858009ca145
출처 데이터셋: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04230865

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