Triphenylphosphine → (3,4,5-Tribromo-2-thenyl)triphenylphosphonium chloride

HRID 904450

반응식

HRID 904450 반응식
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][C:21]1[C:25]([Br:26])=[C:24]([Br:27])[S:23][C:22]=1[CH2:28][Cl:29]>C1(C)C=CC=CC=1>[Cl-:29].[Br:20][C:21]1[C:25]([Br:26])=[C:24]([Br:27])[S:23][C:22]=1[CH2:28][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 151249082,3,4-Tribromo-5-(chloromethyl)thiophene

생성물 1

HCID 20285678(3,4,5-Tribromo-2-thenyl)triphenylphosphonium chloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Triphenylphosphine (9.0 g.) and 10.4 g. of 3,4,5-tribromo-2-chloromethylthiophene were dissolved in 200 ml. of toluene. The mixture was refluxed overnight under argon, cooled to room temperature and the precipitated phosphonium salt was collected by filtration, washed several times with cold benzene and dried at 80° C. under high vacuum. The resulting (3,4,5-tribromo-2-thenyl)triphenylphosphonium chloride has a m.p. 248°-249° C.

후처리

  1. temperatureThe mixture was refluxed overnight under argon
  2. filtrationthe precipitated phosphonium salt was collected by filtration
  3. washwashed several times with cold benzene
  4. customdried at 80° C. under high vacuum

출처 및 근거

ORD 기록
ord-784c2b5116a447119fb3b025dce51292
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04230872

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