Acetic Acid → HCID 20285752, 화합물

HRID 904451노트

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HRID 904451 반응식
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([Br:8])[C:6]=1[Br:7].C(O)(=O)C.[ClH:13].[CH2:14]=O>O>[Cl:13][CH2:1][C:2]1[S:3][C:4]([CH3:14])=[C:5]([Br:8])[C:6]=1[Br:7]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 128752643,4-Dibromo-2-methylthiophene

생성물 1

HCID 20285752HCID 20285752, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

A solution of 11.7 g. of 2-methyl-3,4-dibromo-thiophene in 30 ml. of acetic acid was added to 60 ml. of concentrated hydrochloric acid. After dropping in 4.1 g of a 37% aqueous solution of formaldehyde the mixture was heated to 70° C. for one hour. The reaction mixture was cooled, diluted with water and extracted with ether. The combined organic phases were washed with water, sodium bicarbonate and water, dried over sodium sulfate, filtered and evaporated to give 2-chloromethyl-3,4-dibromo-5-methyl-thiophene.

후처리

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with ether
  3. washThe combined organic phases were washed with water, sodium bicarbonate and water
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-b6885309de144b5d9f3eec663a0e8766
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04230872

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