Ethanol → (2,4-Dimethylthiophen-3-yl)methanol

HRID 904472노트

반응식

HRID 904472 반응식
[BH4-].[Na+].[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH:9]=[O:10].C(O)C>O>[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH2:9][OH:10]

참가 물질

5

반응물 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 111477702,4-Dimethylthiophene-3-carbaldehyde

생성물 1

HCID 12875266(2,4-Dimethylthiophen-3-yl)methanol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

0.68 G. (18 mmol) of sodium borohydride was added in three portions to a solution of 10.08 g. (72 mmol) of 2,4-dimethylthiophene-3-carboxaldehyde in 120 ml. of ethanol. After 15 min., the reaction mixture was poured into water, extracted with ether, dried and the solvent evaporated. The resulting residue was recrystallized from hexane to yield 2,4-dimethyl-3-hydroxymethylthiophene, m.p. 80°-81° C.

후처리

  1. extractionextracted with ether
  2. customdried
  3. customthe solvent evaporated
  4. customThe resulting residue was recrystallized from hexane

출처 및 근거

ORD 기록
ord-b7d87ca55c9d4cf4a21bc8b6ee985286
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04230872

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