Nitric Acid → HCID 20478438, 화합물

HRID 904681노트

반응식

HRID 904681 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[C:7]([OH:14])[C:6]=1[CH2:15][CH2:16][CH3:17])(=[O:3])[CH3:2].C(OC(=O)C)(=O)C.[N+:25]([O-])([OH:27])=[O:26]>C(O)(=O)C>[C:1]([NH:4][C:5]1[C:10]([N+:25]([O-:27])=[O:26])=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[C:7]([OH:14])[C:6]=1[CH2:15][CH2:16][CH3:17])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 7918Acetic AnhydrideHCID 2775203N1-(4-acetyl-3-hydroxy-2-propylphenyl)acetamide

생성물 1

HCID 20478438HCID 20478438, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

1-(4-Acetylamino-2-hydroxy-3-propylphenyl)ethanone (58.75 g) was suspended in glacial acetic acid (750 ml), and this suspension was treated with a mixture of glacial acetic acid (250 ml), acetic anhydride (48 ml) and conc. nitric acid (10.2 ml) with vigorous stirring. After 18 hours the insoluble material was collected and dried in vacuo to afford the title compound 29.1 g. The structure was confirmed by NMR and mass spectrometry.

후처리

  1. customAfter 18 hours the insoluble material was collected
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-7cdc0735ca034538983991f8b9caf3f7
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04419352

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