N-Trimethylsilyl-N-methylacetamide → 1-Isopropylsulfonyl-2-amino-6-(alpha-hydroxy-alpha-methylaminocarbonylmethylbenzyl)benzimidazole

HRID 904829노트

반응식

HRID 904829 반응식
[CH3:1][N:2]([Si](C)(C)C)[C:3](=[O:5])[CH3:4].[CH:10]([S:13]([N:16]1[C:20]2[CH:21]=[C:22]([C:25](=[O:32])[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[NH2:33])(=[O:15])=[O:14])([CH3:12])[CH3:11].C([Li])CCC>>[CH:10]([S:13]([N:16]1[C:20]2[CH:21]=[C:22]([C:25]([OH:32])([CH2:4][C:3]([NH:2][CH3:1])=[O:5])[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[NH2:33])(=[O:14])=[O:15])([CH3:12])[CH3:11]

참가 물질

4

반응물 3

HCID 81953N-Trimethylsilyl-N-methylacetamideHCID 30173892-Amino-6-benzoyl-1-((isopropyl)sulphonyl)-1H-benzimidazoleHCID 178418339Butyllithium

생성물 1

HCID 132864991-Isopropylsulfonyl-2-amino-6-(alpha-hydroxy-alpha-methylaminocarbonylmethylbenzyl)benzimidazole

실험 절차

Following the general procedure of Example 23, N-methyl-N-trimethylsilylacetamide was reacted with 1-isopropylsulfonyl-2-amino-6-benzoylbenzimidazole in the presence of n-butyl lithium to provide 1-isopropylsulfonyl-2-amino-6-(α-hydroxy-α-methylaminocarbonylmethylbenzyl)benzimidazole. M.P. 92°-95° C.

출처 및 근거

ORD 기록
ord-f4e5e231920543f78ea358305d2adef3
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04420479

반응 노트

불러오는 중…