3-Chlorocyclopent-1-ene → 2-(cyclopent-2-en-1-yloxy)-2,3-dihydro-1H-isoindole-1,3-dione

HRID 904871

반응식

HRID 904871 반응식
Cl[CH:2]1[CH2:6][CH2:5][CH:4]=[CH:3]1.[OH:7][N:8]1[C:12](=[O:13])[C:11]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]2[C:9]1=[O:18].C(N(CC)CC)C>C(#N)C>[CH:2]1([O:7][N:8]2[C:9](=[O:18])[C:10]3=[CH:17][CH:16]=[CH:15][CH:14]=[C:11]3[C:12]2=[O:13])[CH2:6][CH2:5][CH:4]=[CH:3]1

참가 물질

5

반응물 3

HCID 72973-Chlorocyclopent-1-eneHCID 8471TriethylamineHCID 10665N-Hydroxyphthalimide

생성물 1

HCID 108469962-(cyclopent-2-en-1-yloxy)-2,3-dihydro-1H-isoindole-1,3-dione수율 69.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 3-chlorocyclopentene (36.9 g), N-hydroxyphthalimide (58.2 g) and triethylamine (53.9 g) in acetonitrile (370 ml) was refluxed for 2 hours. The reaction mixture was poured into ice-water. The precipitated crystals were collected by filtration, washed with water and dried over phosphorus pentoxide to give N-(2-cyclopenten-1-yl)oxyphthalimide (56.5 g).

후처리

  1. temperaturewas refluxed for 2 hours
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water
  4. dry with materialdried over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-7126baaf6c104960b20a7e78baa621b8
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04420477

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