Hydrochloric Acid → N-[4-(cyanoacetyl)phenyl]propane-1-sulfonamide

HRID 904881노트

반응식

HRID 904881 반응식
[CH2:1]([S:4](Cl)(=[O:6])=[O:5])[CH2:2][CH3:3].C(OC)(=O)C.[NH2:13][C:14]1[CH:24]=[CH:23][C:17]([C:18]([CH2:20][C:21]#[N:22])=[O:19])=[CH:16][CH:15]=1.Cl>CO.N1C=CC=CC=1>[CH2:1]([S:4]([NH:13][C:14]1[CH:15]=[CH:16][C:17]([C:18]([CH2:20][C:21]#[N:22])=[O:19])=[CH:23][CH:24]=1)(=[O:6])=[O:5])[CH2:2][CH3:3]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6584Methyl AcetateHCID 662791-Propanesulfonyl chlorideHCID 96920Benzenepropanenitrile, 4-amino-beta-oxo-

생성물 1

HCID 19737109N-[4-(cyanoacetyl)phenyl]propane-1-sulfonamide

시약·촉매·용매 2

HCID 887Methanol용매HCID 1049Pyridine용매

실험 절차

Dry pyridine (13 ml) was added dropwise to a stirred mixture of 14.3 g (0.1 mole) 1-propanesulfonyl chloride, 15 ml dry methyl acetate and 16.0 g (0.1 mole) 4-aminobenzoylacetonitrile at room temperature. An ice bath was then used to control the exothermic reaction and the mixture was stirred in the ice bath for two hours. Methanol (50 ml) was added and the resulting solution poured into 2 N hydrochloric acid (240 ml) with stirring. The solid was collected, washed with water and dried. Yield 20.7 g (78%). Recrystallization yielded product melting at 150°-151° C.

후처리

  1. customAn ice bath was then used
  2. customthe exothermic reaction
  3. customThe solid was collected
  4. washwashed with water
  5. customdried
  6. customRecrystallization

출처 및 근거

ORD 기록
ord-b4f528ab21f442ddbee4020299ea6d00
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04420555

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