Dimethylamine → [(2,3-Dichloro-phenyl)-(1-methyl-1H-indol-3-yl)-methyl]-dimethyl-amine

반응식

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[Cl-].[Cl:12][C:13]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:14]=1[CH:15]=[N+:16]([CH3:18])[CH3:17].ClC1C(Cl)=CC=CC=1C=O.CNC>>[Cl:12][C:13]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:14]=1[CH:15]([N:16]([CH3:18])[CH3:17])[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:2]([CH3:1])[CH:3]=1

참가 물질

반응물 4

HCID 674Dimethylamine

HCID 117811-Methylindole

HCID 357452,3-Dichlorobenzaldehyde

HCID 21985372(2,3-Dichloro-benzylidene)-dimethyl-ammonium chloride

생성물 1

HCID 21985332[(2,3-Dichloro-phenyl)-(1-methyl-1H-indol-3-yl)-methyl]-dimethyl-amine

실험 절차

The preparation was carried out in accordance with general synthesis instructions 4 from 1-methylindole and (2,3-dichloro-benzylidene)-dimethyl-ammonium chloride, which had been prepared in accordance with example 24 from 2,3-dichloro-benzaldehyde and dimethylamine.

출처 및 근거

ORD 기록: ord-e628563da2734892a93257119bfd4b8e
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07091220B2

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