Dimethyl Sulfate → N-(alpha-Cyano-3-phenoxybenzyl)-N,N,N-trimethylammonium methylsulfate

HRID 904901노트

반응식

HRID 904901 반응식
[S:1]([O:6]C)([O:4][CH3:5])(=[O:3])=[O:2].[CH3:8][N:9]([CH3:26])[CH:10]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:14]=1)[C:11]#[N:12]>CC(CC)=O>[CH3:5][O:4][S:1]([O-:6])(=[O:3])=[O:2].[C:11]([CH:10]([N+:9]([CH3:5])([CH3:26])[CH3:8])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:14]=1)#[N:12]

참가 물질

4

반응물 2

HCID 6497Dimethyl SulfateHCID 13565187alpha-(Dimethylamino)-3-phenoxybenzeneacetonitrile

생성물 1

HCID 13565188N-(alpha-Cyano-3-phenoxybenzyl)-N,N,N-trimethylammonium methylsulfate수율 203.7%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

Dimethyl sulfate (2.52 g) was added to a solution of α-(dimethylamino)-3-phenoxybenzeneacetonitrile (5.2 g) in ethyl methyl ketone (40 ml) and the mixture was stirred overnight at ambient temperature. The solvent was removed by distillation under reduced pressure to give the title compound (7.7 g) as a golden oil. Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 3.4 (9H, s, N(CH3)3); 3.65 (3H, s, CH3SO4); 6.7 (1H, s, CH); 7.0-7.7 (9H, m, aromatic protons).

후처리

  1. customThe solvent was removed by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-392d9d74b82e46f1983ac4eda1fce2d4
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04420614

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