Acetone → HCID 178481590, 화합물

HRID 904991노트

반응식

HRID 904991 반응식
[CH3:1][C:2]([C:5]1[O:9][N:8]=[C:7]([N:10]2[CH:14]([OH:15])[CH:13]([OH:16])[N:12]([CH3:17])[C:11]2=[O:18])[CH:6]=1)([CH3:4])[CH3:3].CC(C)=O>Cl(O)(=O)(=O)=O.O>[CH2-:2][C:5]([CH3:6])=[O:9].[CH3:4][C:2]([C:5]1[O:9][N:8]=[C:7]([N:10]2[CH:14]([OH:15])[CH:13]([OH:16])[N:12]([CH3:17])[C:11]2=[O:18])[CH:6]=1)([CH3:1])[CH3:3]

참가 물질

5

반응물 2

HCID 180AcetoneHCID 12918841HCID 12918841, 화합물

생성물 1

HCID 178481590HCID 178481590, 화합물

시약·촉매·용매 2

HCID 24247Perchloric Acid촉매HCID 962Water용매

실험 절차

To a solution of 1.0 gram of 3-[5-(1,1-dimethylethyl)-3-isoxazolyl]-4,5-dihydroxy-1-methyl-2-imidazolidinone in 20 ml. of anhydrous acetone were added three drops of 70% perchloric acid. The reaction mixture stood at ambient temperature for sixteen hours, and then was diluted with 100 ml. of water. The white crystalline precipitate was collected by filtration and recrystallized from diethyl ether and hexane to afford 3-[5-(1,1-dimethylethyl)-3-isoxazolyl]-4,5-dihydroxy-1-methyl-2-imidazolidinone acetonide. M.P. 157°-159° C. Mass Spectrum M+Theory 295; Found 295.

후처리

  1. waitThe reaction mixture stood at ambient temperature for sixteen hours
  2. additionwas diluted with 100 ml
  3. filtrationThe white crystalline precipitate was collected by filtration
  4. customrecrystallized from diethyl ether and hexane

출처 및 근거

ORD 기록
ord-bc3a74810f1d4c4799a5abc188ed5977
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04421546

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