Iodoacetamide → HCID 20475727, 화합물

반응식

Cl.[CH3:2][C:3]1[C:8]([Br:9])=[C:7]([CH3:10])[NH:6][C:5](=[S:11])[N:4]=1.[OH-].[K+].I[CH2:15][C:16]([NH2:18])=[O:17]>>[C:16]([CH2:15][S:11][C:5]1[N:6]=[C:7]([CH3:10])[C:8]([Br:9])=[C:3]([CH3:2])[N:4]=1)(=[O:17])[NH2:18]

참가 물질

반응물 3

HCID 3727Iodoacetamide

HCID 14797Potassium Hydroxide

HCID 20475758HCID 20475758, 화합물

생성물 1

HCID 20475727HCID 20475727, 화합물수율 72%

실험 절차

4,6-Dimethyl-5-bromopyrimidine-2-thione HCl salt (5 mmol) was added to ethanolic (60 ml) KOH (11.4 mmol), the solution stirred for 10 min at room temperature, iodoacetamide (5.7 mmol) added, the stirring continued for 20 min at room temperature and for 100 min at 70° C. (pH 8). The warm reaction mixture was filtered, the filtrate evaporated, the residue extracted with chloroform (150 ml), the chloroform solution washed and the dried (MgSO4) solution evaporated to leave the sulfide; yield 72%, m.p. 175°-177° C. (iPrOH). 1H NMR (DMSO-d6): δ2.50 (Me), 3.80 (SCH2).

후처리

waitthe stirring continued for 20 min at room temperature and for 100 min at 70° C.
customThe warm reaction mixture
filtrationwas filtered
customthe filtrate evaporated
extractionthe residue extracted with chloroform (150 ml)
washthe chloroform solution washed
dry with materialthe dried (MgSO4) solution
customevaporated

출처 및 근거

ORD 기록: ord-f8ddfa65af6b4e8a8b3021742794d2bf
출처 데이터셋: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04423047

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