p-Toluenesulfonic acid → 2-Tetrahydropyranyl 4-(8-cyclohexyloctylamino)benzoate

HRID 905274노트

반응식

HRID 905274 반응식
[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:25]1[CH:30]=[CH:29][CH2:28][CH2:27][CH2:26]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([O:22][CH:26]3[CH2:27][CH2:28][CH2:29][CH2:30][O:25]3)=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 204757724-(8-Cyclohexyloctylamino)benzoic acid

생성물 1

HCID 204758342-Tetrahydropyranyl 4-(8-cyclohexyloctylamino)benzoate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 7 g. 4-(8-cyclohexyloctylamino)benzoic acid, 2 g. 2,3-dihydropyran and 100 mg. anhydrous p-toluenesulfonic acid in 50 ml. toluene is stirred at room temperature for 20 hours. The solution is washed with saturated sodium bicarbonate, dried, and condensed. The residue is crystallized from methylcyclohexane to white crystals.

후처리

  1. additionA mixture of 7 g
  2. washThe solution is washed with saturated sodium bicarbonate
  3. customdried
  4. customcondensed
  5. customThe residue is crystallized from methylcyclohexane to white crystals

출처 및 근거

ORD 기록
ord-82e37ac1a3fc4c2c9dac6c33089a34dd
출처 데이터셋
uspto-grants-1983_12
특허 번호
US04423051

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