Formic Acid → N-(5-fluoro-2-oxo-2,3-dihydro-1H-indol-7-yl)-formamide
반응식
[C:1](OC(=O)C)(=[O:3])C.C(O)=O.[NH2:11][C:12]1[CH:13]=[C:14]([F:22])[CH:15]=[C:16]2[C:20]=1[NH:19][C:18](=[O:21])[CH2:17]2>O1CCCC1.N1CCCCC1>[F:22][C:14]1[CH:15]=[C:16]2[C:20](=[C:12]([NH:11][CH:1]=[O:3])[CH:13]=1)[NH:19][C:18](=[O:21])[CH2:17]2참가 물질
6
실험 절차
A solution of acetic anhydride (0.8 ml) and formic acid (0.6 ml) was stirred for 1 hour at room temperature, and added with 7-amino-5-fluoro-1,3-dihydro-indol-2-one (2.0 g, 12 mmol) obtained from Example 4 in 30 ml of tetrahydrofuran and piperidine (0.02 ml). The resulting mixture was stirred for 3 hours at room temperature until a precipitate was formed. The solid was filtered and recrystallized from methanol to give N-(5-fluoro-2-oxo-2,3-dihydro-1H-indol-7-yl)-formamide (700 mg, 30.4%) as a white solid.
후처리
- customwas formed
- filtrationThe solid was filtered
- customrecrystallized from methanol
출처 및 근거
- ORD 기록
- ord-d7f34544f2d84435951e6aa2e3e72042
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08012966B2
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