Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenethyl isocyanate → 1-phenethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenethyl isocyanate | HCID 160602 | — |
| 반응물 | 5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine | HCID 59363369 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-phenethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea | HCID 59363365 | 55% |
반응 단계
A solution of 5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine (0.260 g, 0.98 mmol) in 15 mL of dichloromethane was cooled to −30° C. Phenethyl isocyanate (0.21 g, 1.5 mmol) was added, and the resulting solution was stirred at room temperature for 14 h, then concentrated to a residue. Column chromatography afforded 0.220 g (55%) of 1-phenethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08012974B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-5546393eb1494906841a9b27754965fc |
| 출처 메모 | uspto-grants-2011_09 |