Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(R)-sec-butylamine → 4-(aminocarbonyl)-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (R)-sec-butylamine | HCID 2724537 | — |
| 반응물 | ethyl 2-bromo-4-cyano-5-{[(1R)-1-methylpropyl]amino}benzoate | HCID 67404527 | — |
| 반응물 | ethyl 4-cyano-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoate | HCID 67405722 | — |
| 생성물 | 4-(aminocarbonyl)-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoic acid | HCID 57748590 | — |
반응 단계
Synthesized according to the method of reagent preparation 50 by using (1R)-1-methylpropylamine in step 1 then following step 2 with the conversion of ethyl 2-bromo-4-cyano-5-{[(1R)-1-methylpropyl]amino}benzoate to ethyl 4-cyano-2-(ethylamino)-5-{[(1R)-1-methylpropyl]amino}benzoate according to the method described in step 1 then proceeding through steps 3 and 4. MS (EI) for C14H21N3O3: 280 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08012956B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-445f68c7ef214569aad75372bc727aca |
| 출처 메모 | uspto-grants-2011_09 |