Methyl iodide → 5,5-Dimethyl-2-methylsulphanyl-3,4,5,6-tetrahydropyrimidinium hydroiodide

HRID 906226

반응식

HRID 906226 반응식
[CH3:1][C:2]1([CH3:9])[CH2:7][NH:6][C:5](=[S:8])[NH:4][CH2:3]1.[I:10][CH3:11]>CO>[IH:10].[CH3:1][C:2]1([CH3:9])[CH2:7][NH+:6]=[C:5]([S:8][CH3:11])[NH:4][CH2:3]1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 38664875,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol

생성물 1

HCID 866001675,5-Dimethyl-2-methylsulphanyl-3,4,5,6-tetrahydropyrimidinium hydroiodide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The reaction mixture comprising one equivalent of 5,5-dimethyl-3,4,5,6-tetrahydro(1H)pyrimidine-2-thione and 1.2 equivalents of iodomethane in methanol (10 ml/g of thio-urea) is heated under reflux for 5 hours. After cooling down, the methanol is evaporated off under reduced pressure in order to quantitatively produce the product. The precipitate can then be washed in acetone or petroleum ether.

후처리

  1. temperatureunder reflux for 5 hours
  2. temperatureAfter cooling down
  3. customthe methanol is evaporated off under reduced pressure in order
  4. customto quantitatively produce the product
  5. washThe precipitate can then be washed in acetone

출처 및 근거

ORD 기록
ord-74e08c4ab9b149f9950b4f135f462d6e
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012985B2

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