홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Benzoyl Peroxide → 6-Bromo-4-(bromomethyl)-2-(phenylsulfonyl)isoquinolin-1(2H)-one

HRID 906415
노트
인쇄 미리보기

반응식

HRID 906415 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([S:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:15])=[O:14])[CH:6]=[C:5]2[CH3:22].[Br:23]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([S:13]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)(=[O:15])=[O:14])[CH:6]=[C:5]2[CH2:22][Br:23]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 574398996-bromo-4-methyl-2-(phenylsulfonyl)isoquinolin-1(2H)-one

생성물 1

HCID 671303306-Bromo-4-(bromomethyl)-2-(phenylsulfonyl)isoquinolin-1(2H)-one수율 61.8%

시약·촉매·용매 1

HCID 241Benzene용매

반응 조건

온도
80 °C

실험 절차

A solution of 6-bromo-4-methyl-2-(phenylsulfonyl)isoquinolin-1(2H)-one (Example 11c, 4.55 g) in benzene (40 mL) was treated with N-bromosuccinimide (3.00 g) and benzoyl peroxide (0.291 g) under nitrogen. The resulting solution was heated at 80° C. for 3 h. The cooled reaction mixture was evaporated to dryness. Purification (SiO2 chromatography, elution with 60% DCM in isohexane) afforded the subtitle compound (3.40 g) as a white solid.

후처리

  1. customThe cooled reaction mixture
  2. customwas evaporated to dryness
  3. customPurification (SiO2 chromatography, elution with 60% DCM in isohexane)

출처 및 근거

ORD 기록
ord-b8345cd40ae14166a5588aa5a0c7a182
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08012980B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트