Lithium Carbonate → 4-[(2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidin-1-yl]-2-fluoro-3-methylbenzonitrile

반응식

[CH2:1]([C@:3]1([OH:9])[CH2:7][CH2:6][NH:5][C@H:4]1[CH3:8])[CH3:2].[F:10][C:11]1[C:18]([CH3:19])=[C:17](F)[CH:16]=[CH:15][C:12]=1[C:13]#[N:14].C(=O)([O-])[O-].[Li+].[Li+]>>[CH2:1]([C@:3]1([OH:9])[CH2:7][CH2:6][N:5]([C:17]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[C:11]([F:10])[C:18]=2[CH3:19])[C@H:4]1[CH3:8])[CH3:2]

참가 물질

반응물 3

HCID 11125Lithium Carbonate

HCID 113441192,4-Difluoro-3-methylbenzonitrile

HCID 59273028(2S,3S)-3-ethyl-2-methylpyrrolidin-3-ol

생성물 1

HCID 592730734-[(2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidin-1-yl]-2-fluoro-3-methylbenzonitrile

실험 절차

By an operation in the same manner as in Example 1 and using (2S,3S)-3-ethyl-2-methylpyrrolidin-3-ol 0.5 oxalate (257 mg), 2,4-difluoro-3-methylbenzonitrile (340 mg) and lithium carbonate (218 mg), the title compound was obtained as colorless oil (yield: 184 mg, yield: 47%).

출처 및 근거

ORD 기록: ord-10804e0f4c54408780fab98ff1dd0822
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08013008B2

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