Lithium Carbonate → 2-chloro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]benzonitrile

반응식

[CH3:1][C@H:2]1[C@@:6]([CH2:8]CC)([OH:7])[CH2:5][CH2:4][NH:3]1.[Cl:11][C:12]1[CH:19]=[C:18](F)[CH:17]=[CH:16][C:13]=1[C:14]#[N:15].C(=O)([O-])[O-].[Li+].[Li+]>>[Cl:11][C:12]1[CH:19]=[C:18]([N:3]2[CH2:4][CH2:5][C@@:6]([OH:7])([CH3:8])[C@@H:2]2[CH3:1])[CH:17]=[CH:16][C:13]=1[C:14]#[N:15]

참가 물질

반응물 3

HCID 11125Lithium Carbonate

HCID 1090002-Chloro-4-fluorobenzonitrile

HCID 59273025(2S,3S)-2-methyl-3-propylpyrrolidin-3-ol

생성물 1

HCID 592730142-chloro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]benzonitrile

실험 절차

By an operation in the same manner as in Example 1 and using (2S,3S)-2,3-dimethylpyrrolidin-3-ol 0.5 oxalate (1.50 g), 2-chloro-4-fluorobenzonitrile (3.04 g) and lithium carbonate (1.04 g), the title compound was obtained as a colorless solid (yield: 1.70 g, yield: 72%).

출처 및 근거

ORD 기록: ord-bd28ed6f0146444dabe6d102bc64f039
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08013008B2

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