Ethanol → 6-Iodoindoline

HRID 907179

반응식

HRID 907179 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([I:13])[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+].CCO>O>[I:13][C:10]1[CH:11]=[C:12]2[C:7]([CH2:6][CH2:5][NH:4]2)=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 116663961-Acetyl-6-iodoindoline

생성물 1

HCID 116156966-Iodoindoline수율 64%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-Acetyl-6-iodoindoline (1.06 g, 3.7 mmol), NaOH (1.16 g, 29 mmol), EtOH (8 mL), and H2O (6 mL) were heated at 90° C. overnight. The reaction mixture was then partitioned between H2O and EtOAc. The organic layer was extracted into aqueous HCl. The aqueous layer was in turn basified with NaOH, and was extracted with EtOAc. The organic layer was dried and concentrated. Hexane trituration yielded 6-iodoindoline (577 mg, 64%) as a brown solid.

후처리

  1. customThe reaction mixture was then partitioned between H2O and EtOAc
  2. extractionThe organic layer was extracted into aqueous HCl
  3. extractionwas extracted with EtOAc
  4. customThe organic layer was dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0ec4d54cb95b4cc78d773166451d5bb4
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013006B2

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