Acetic Acid → 6-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid

HRID 907274노트

반응식

HRID 907274 반응식
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:32])=[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19](=[O:23])[N:18]([CH2:24][CH:25]3[CH2:27][CH2:26]3)[CH:17]=[C:16]4[C:28]([O:30]C)=[O:29])[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[OH-].[Na+].C(O)(=O)C.O>CO>[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:32])=[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[C:19](=[O:23])[N:18]([CH2:24][CH:25]3[CH2:27][CH2:26]3)[CH:17]=[C:16]4[C:28]([OH:30])=[O:29])[CH:12]=2)=[O:6])[CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 57551825HCID 57551825, 화합물

생성물 1

HCID 575517606-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of the product of step iv) (1.5 g) in methanol (20 mL) at reflux was added sodium hydroxide (1N, 5.23 mL) and the solution stirred at this temperature for 30 min. The reaction mixture was treated with acetic acid (0.34 mL) and water and stirred overnight at room temperature. The solid was filtered and washed with methanol:water (1:1) then water. The solid was dried under vacuum at 60° C. to yield the sub-title compound (1.25 g).

후처리

  1. stirringstirred overnight at room temperature
  2. filtrationThe solid was filtered
  3. washwashed with methanol:water (1:1)
  4. customThe solid was dried under vacuum at 60° C.

출처 및 근거

ORD 기록
ord-41c16bf2485f4cccb24807ae1a4ed3d9
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012979B2

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