Hydrochloric Acid → Ethyl 2-formyl-1,3-thiazole-4-carboxylate

HRID 907380노트

반응식

HRID 907380 반응식
C([O:3][CH:4](OCC)[C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)C.Cl>CC(C)=O>[CH:4]([C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)=[O:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 16220290Ethyl 2-(diethoxymethyl)thiazole-4-carboxylate

생성물 1

HCID 11355896Ethyl 2-formyl-1,3-thiazole-4-carboxylate수율 98%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Ethyl 2-(diethoxymethyl)-1,3-thiazole-4-carboxylate (1.34 g, 5.17 mmol; see step (iv) above) was taken up in acetone (100 mL) and a solution of 1N HCl (12.8 mL) was then added. The solution was refluxed for 45 min and the solvent removed under reduced pressure. The residue was then dissolved in ethyl acetate (40 mL) and extracted with saturated NaHCO3 solution (2×40 mL) and brine (2×40 mL). The organic fraction was then dried (MgSO4), filtered and the solvent removed under reduced pressure to yield the sub-title compound as a light brown solid (0.937 g, 98%).

후처리

  1. temperatureThe solution was refluxed for 45 min
  2. customthe solvent removed under reduced pressure
  3. dissolutionThe residue was then dissolved in ethyl acetate (40 mL)
  4. extractionextracted with saturated NaHCO3 solution (2×40 mL) and brine (2×40 mL)
  5. dry with materialThe organic fraction was then dried (MgSO4)
  6. filtrationfiltered
  7. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-11a31948ecc140d4be71da7899c446b1
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012967B2

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