Tert-butyl 4-(4-chloro-1,2,5-thiadiazol-3-yl)piperazine-1-carboxylate → 1-(4-Chloro-[1,2,5]thiadiazol-3-yl)piperazine hydrochloride

HRID 907542

반응식

HRID 907542 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:18]([Cl:19])=[N:17][S:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[ClH:19].[Cl:19][C:18]1[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:15][S:16][N:17]=1

참가 물질

4

반응물 1

HCID 15524001Tert-butyl 4-(4-chloro-1,2,5-thiadiazol-3-yl)piperazine-1-carboxylate

생성물 1

HCID 212020421-(4-Chloro-[1,2,5]thiadiazol-3-yl)piperazine hydrochloride수율 191.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

4-(4-Chloro-[1,2,5]thiadiazol-3-yl)piperazine-1-carboxylic acid tert-butyl ester (1.0 g, 3.28 mmol) was suspended in 10 mL of 4 M HCl in dioxane. The suspension was stirred overnight and the solid material was removed by filtration. The solid was washed three times with 15 mL ethyl acetate and dried under vacuum. 756 mg of white powder was obtained.

후처리

  1. customthe solid material was removed by filtration
  2. washThe solid was washed three times with 15 mL ethyl acetate
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-2e205e0847fa4600a4b442f995ea3e82
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08013156B2

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