Sulfuric acid magnesium salt (1:1) → HCID 178519079, 화합물

HRID 908038

반응식

HRID 908038 반응식
[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[CH:13]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:15][C:16]1[CH:24]=[CH:23][CH:22]=[C:21]2[C:17]=1[CH2:18][O:19][C:20]2=[O:25].S([O-])([O-])(=O)=O.[Mg+2]>C(#N)C>[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1/[CH:13]=[N:15]/[C:16]1[CH:24]=[CH:23][CH:22]=[C:21]2[C:17]=1[CH2:18][O:19][C:20]2=[O:25])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 1390821-benzyl-1H-imidazole-2-carbaldehydeHCID 122846494-Amino-1,3-dihydro-2-benzofuran-1-one

생성물 1

HCID 178519079HCID 178519079, 화합물수율 100.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The mixture of 1-benzyl-1H-imidazole-2-carbaldehyde (430 mg, 1.48 mmol), 4-aminoisobenzofuran-1(3H)-one (221 mg, 1.48 mmol) and magnesium sulfate (4.3 g) in acetonitrile was heated to reflux for 48 hr. Then the mixture was filtrated off and evaporated to remove the solvent. The crude was re-crystallized from isopropanol to obtain the title compound (470 mg, 65%). LC-MS (ESI) m/z: 318 (M+1)+.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 48 hr
  3. filtrationThen the mixture was filtrated off
  4. customevaporated
  5. customto remove the solvent
  6. customThe crude was re-crystallized from isopropanol

출처 및 근거

ORD 기록
ord-a7b753ab10104293817030635d0a43c4
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012976B2

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