Water → 2-Phenylimidazo[1,2-c]pyrimidin-7-amine

HRID 908236

반응식

HRID 908236 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.C([O-])(O)=O.[Na+].[NH2:16][C:17]1[CH:22]=[C:21]([NH2:23])[N:20]=[CH:19][N:18]=1.O>CO>[C:5]1([C:3]2[N:16]=[C:17]3[CH:22]=[C:21]([NH2:23])[N:20]=[CH:19][N:18]3[CH:2]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6259Phenacyl bromideHCID 79608Pyrimidine-4,6-diamineHCID 516892Sodium Bicarbonate

생성물 1

HCID 4040512-Phenylimidazo[1,2-c]pyrimidin-7-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

ω-Bromoacetophenone (9.04 g, 45 mmol) and NaHCO3 (4.30 g, 50 mmol) were added to a solution of 4,6-diaminopyrimidine (5.00 g, 0.45 mmol) in methanol (80 ml), and the mixture was heated to reflux (3 h). Upon cooling, water (40 ml) was added, and the suspension was stirred at r.t. (15 min). The precipitated title compound (5.62 g, 59%) was isolated by filtration, washed with small amounts of water and methanol, and dried under vacuum. MS (m/e)=211.1 [M+H+].

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux (3 h)
  3. temperatureUpon cooling
  4. customThe precipitated title compound (5.62 g, 59%)
  5. customwas isolated by filtration
  6. washwashed with small amounts of water and methanol
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-977e643049e748a8ae969dd88ddb423f
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017604B2

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