Hydrochloric Acid → HCID 11186874, 화합물

HRID 908823노트

반응식

C[O:2][C:3](=[O:25])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[C:10]([Cl:24])[C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7].Cl.C([O-])(O)=O.[Na+]>>[Cl:24][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:8]([C:6]([NH:5][CH2:4][C:3]([OH:25])=[O:2])=[O:7])[N:9]=1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 516892Sodium Bicarbonate

HCID 86014604HCID 86014604, 화합물

생성물 1

HCID 11186874HCID 11186874, 화합물수율 73.4%

실험 절차

A mixture of [(1-chloro-4-phenyl-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (50 mg, 0.14 mmol, Example D-74 b), and aqueous 6N HCl was stirred at ambient temperature for 11 days before the solution was neutralized by the addition of concentrated aqueous NaHCO3. The mixture was extracted with EtOAc (50 ml). The organic phase was dried over MgSO4 and concentrated in vacuo to give the title compound as a white solid (35 mg); MS-(+)-ion: M+1=341.0.

후처리

extractionThe mixture was extracted with EtOAc (50 ml)
dry with materialThe organic phase was dried over MgSO4
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-f8bf767803fb441bb09c4ef9167678d3
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08017625B2

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