반응식
Br[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:14]([CH2:15][C:16]([CH3:19])([OH:18])[CH3:17])[C:13]([CH2:20][O:21][CH2:22][CH3:23])=[N:12][C:7]=3[CH:8]=[N:9][C:10]=2[CH:11]=1.BrC1C=CC2C3N(CCCOC(C)C)C(COCC)=NC=3C=[N:32]C=2C=1.[CH2:49]([N:51]1[CH2:55][CH2:54][NH:53][C:52]1=[O:56])[CH3:50].N1CCCC1=O>>[NH2:32][C:8]1[C:7]2[N:12]=[C:13]([CH2:20][O:21][CH2:22][CH3:23])[N:14]([CH2:15][C:16]([OH:18])([CH3:19])[CH3:17])[C:6]=2[C:5]2[CH:4]=[CH:3][C:2]([N:53]3[CH2:54][CH2:55][N:51]([CH2:49][CH3:50])[C:52]3=[O:56])=[CH:11][C:10]=2[N:9]=1참가 물질
5
반응물 4
생성물 1
실험 절차
The general methods described in Parts A and B of Example 2 were followed using 1-(7-bromo-2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol in lieu of 7-bromo-2-ethoxymethyl-1-(3-isopropoxypropyl)-1H-imidazo[4,5-c]quinoline and 1-ethylimidazolidin-2-one in lieu of 2-pyrrolidinone. The product, 1-[4-amino-2-ethoxymethyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-yl]-3-ethylimidazolidin-2-one was isolated as a peach colored crystalline solid, m.p. 210-212° C.
출처 및 근거
- ORD 기록
- ord-f9ecb8c10eba4f188618a3119ecd3146
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08017779B2
연결된 노트
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