Hydrochloric Acid → N-Cyclohexyl-3-(3-(oxazol-5-yl)phenethoxy)-N-(2-oxoethyl)propanamide

HRID 909909노트

반응식

HRID 909909 반응식
[CH:1]1([N:7]([CH2:26][CH:27](OC)[O:28]C)[C:8](=[O:25])[CH2:9][CH2:10][O:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[O:24][CH:23]=[N:22][CH:21]=3)[CH:15]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>CC(C)=O>[CH:1]1([N:7]([CH2:26][CH:27]=[O:28])[C:8](=[O:25])[CH2:9][CH2:10][O:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[O:24][CH:23]=[N:22][CH:21]=3)[CH:15]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59290488N-Cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(oxazol-5-yl)phenethoxy)propanamide

생성물 1

HCID 59290455N-Cyclohexyl-3-(3-(oxazol-5-yl)phenethoxy)-N-(2-oxoethyl)propanamide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a stirred solution of N-cyclohexyl-N-(2,2-dimethoxyethyl)-3-(3-(oxazol-5-yl)phenethoxy)propanamide [Example 10, Step iii)] (660 mg) in acetone (30 mL) was added 2M hydrochloric acid (10 mL). The mixture was stirred for 6 h before the solvents were removed followed by the addition of saturated sodium hydrogen carbonate until basic. The mixture was extracted three times with ethyl acetate, and the pooled organic fractions were washed once with brine, dried over sodium sulphate, filtered and evaporated to afford the sub-titled compound (525 mg). This material was used in the next step directly.

후처리

  1. customwere removed
  2. additionfollowed by the addition of saturated sodium hydrogen carbonate until basic
  3. extractionThe mixture was extracted three times with ethyl acetate
  4. washthe pooled organic fractions were washed once with brine
  5. dry with materialdried over sodium sulphate
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-9c38f9c3d2e44b77bbdded6f82e442e6
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08017602B2

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