2-Amino-5-chloropyridine → 5-[4-(6-Chloroimidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-oxazole

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:23][CH:22]=[N:21][CH:20]=2)=[CH:15][CH:14]=1)=O>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[O:23][CH:22]=[N:21][CH:20]=4)=[CH:15][CH:14]=3)[N:1]=2)[CH:4]=1

참가 물질

반응물 2

HCID 661742-Amino-5-chloropyridine

HCID 866318862-Bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone

생성물 1

HCID 252041195-[4-(6-Chloroimidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-oxazole수율 27%

실험 절차

The procedure of Referential Example 1 was repeated, except that 2-amino-5-chloropyridine (49 mg) and 2-bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone (100 mg), which had been produced in Referential Example 10 were used, to thereby yield the title compound (30 mg).

후처리

customhad been produced in Referential Example 10

출처 및 근거

ORD 기록: ord-3fcb4a2578e24390a13189413608667a
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08022075B2

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