Acetone → 3-(4-Isopropyl-piperazin-1-yl)-phenol

HRID 910274

반응식

HRID 910274 반응식
[CH3:1][C:2]([CH3:4])=O.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].[N:19]1([C:25]2[CH:26]=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.C(=O)(O)[O-].[Na+]>C1COCC1>[CH:2]([N:22]1[CH2:21][CH2:20][N:19]([C:25]2[CH:26]=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=2)[CH2:24][CH2:23]1)([CH3:4])[CH3:1]

참가 물질

6

반응물 4

HCID 180AcetoneHCID 516892Sodium BicarbonateHCID 27365971-(3-Hydroxyphenyl)piperazineHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 584994803-(4-Isopropyl-piperazin-1-yl)-phenol수율 59.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Acetone (1.95 g) and NaBH(OAc)3 (7.12 g) were added to a solution of 3-piperazin-1-yl-phenol (2.00 g) in THF (40 ml), and the mixture was stirred at room temperature for 18 hours. Saturated aqueous sodium bicarbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was dried (MgSO4) and filtered to give the titled compound (1.48 g, colorless powder).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-f0cc949488174e2aa69b178879108f42
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022091B2

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