Acetic Anhydride → HCID 67348858, 화합물

HRID 910577노트

반응식

HRID 910577 반응식
[CH2:1]([C:8]1[C:9](=[O:16])[NH:10][NH:11][C:12]=1[CH:13]([CH3:15])[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>O1CCCC1.C(O)(=O)C>[C:17]([N:11]1[C:12]([CH:13]([CH3:14])[CH3:15])=[C:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9](=[O:16])[NH:10]1)(=[O:19])[CH3:18]

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 673516914-Benzyl-1,2-dihydro-5-isopropyl-3H-pyrazol-3-one

생성물 1

HCID 67348858HCID 67348858, 화합물수율 77%

시약·촉매·용매 2

HCID 176Acetic Acid촉매HCID 8028Tetrahydrofuran용매

실험 절차

4-Benzyl-1,2-dihydro-5-isopropyl-3H-pyrazol-3-one (1.50 g) was dissolved in tetrahydrofuran (6.0 g) at room temperature. Acetic anhydride (0.708 g) and acetic acid (0.0208 g) was added to the solution successively. After the reaction mixture was stirred at room temperature for 15 hours, the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (The product was eluted with dichloromethane at first, and then n-hexane/ethyl acetate=4/1) to give 1-acetyl-4-benzyl-1,2-dihydro-5-isopropyl-3H-pyrazol-3-one (1.38 g).

후처리

  1. customthe solvent was removed under reduced pressure
  2. customThe residue was purified by column chromatography on silica gel (The product
  3. washwas eluted with dichloromethane at first, and then n-hexane/ethyl acetate=4/1)

출처 및 근거

ORD 기록
ord-579bd2bac8bb45139b4b49b6448392db
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022192B2

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