1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

HRID 910681노트

반응식

HRID 910681 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CCO>[Cl:1][C:2]1[N:7]=[C:6]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 531671-MethylpiperazineHCID 775312,4-Dichloropyrimidine

생성물 1

HCID 17142252-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2,4-dichloropyrimidine (740 mg, 5 mmol) in EtOH (15 mL) was slowly added 1-methylpiperazine (550 mg, 5.5 mmol). The resulting mixture was stirred at room temperature overnight, then was concentrated, diluted with water, and extracted with CH2Cl2. The organic layer was dried and concentrated to yield 2-chloro-4-(4-methyl-piperazin-1-yl)-pyrimidine.

후처리

  1. concentrationwas concentrated
  2. additiondiluted with water
  3. extractionextracted with CH2Cl2
  4. customThe organic layer was dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-73e60837939b41ff82c9ae5a0b6276c6
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022209B2

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