1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

HRID 910690노트

반응식

HRID 910690 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>C(O)C>[Cl:1][C:2]1[N:7]=[C:6]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 531671-MethylpiperazineHCID 775312,4-Dichloropyrimidine

생성물 1

HCID 17142252-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2,4-dichloropyrimidine (447 mg, 3 mmol) in ethanol (10 mL) was added 1-methylpyperazine (360 mg, 3.6 mmol). The resulting mixture was stirred at room temperature overnight. The resulting white solid was collected by filtration and washed with ethanol, Na2CO3 solution and water and ethanol.

후처리

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed with ethanol, Na2CO3 solution and water and ethanol

출처 및 근거

ORD 기록
ord-5aa3ce636099429b85a813584cc09145
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022209B2

반응 노트

불러오는 중…