Methyl chloroformate → Methyl (2-(hydroxymethyl)phenyl)carbamate

HRID 910758노트

반응식

HRID 910758 반응식
N[CH:2]([OH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:10][O:11][C:12](Cl)=[O:13].CC[N:17](C(C)C)C(C)C>>[CH3:10][O:11][C:12](=[O:13])[NH:17][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][OH:9]

참가 물질

4

반응물 3

HCID 6586Methyl chloroformateHCID 81531DiisopropylethylamineHCID 5250324HCID 5250324, 화합물

생성물 1

HCID 54236756Methyl (2-(hydroxymethyl)phenyl)carbamate

실험 절차

Reaction of aminobenzylalcohol (3 g) with methylchloroformate (1.9 ml) in the presence of DIPEA (12.8 ml) was performed according to the method described in example 22. The residue was chromatographed on silica gel in dichloromethane/ethyl acetate=25/1 as eluent. Yield: 4.19 g.

후처리

  1. customThe residue was chromatographed on silica gel in dichloromethane/ethyl acetate=25/1 as eluent

출처 및 근거

ORD 기록
ord-e86d56d26b9943a5a3ca7936ef4d82d8
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022218B2

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