Ammonium Acetate → (s)-3-Amino-but-2-enoic acid [1-(4-methoxy-phenyl)-ethyl]-amide

HRID 910762노트

반응식

HRID 910762 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:12](=[O:17])[CH2:13][C:14](=O)[CH3:15])[CH3:10])=[CH:5][CH:4]=1.C([O-])(=O)C.[NH4+:22]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:12](=[O:17])[CH:13]=[C:14]([NH2:22])[CH3:15])[CH3:10])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 517165Ammonium AcetateHCID 86624412(1S)-N-[1-(4-Methoxy-phenyl)-ethyl]-3-oxo-butyramide

생성물 1

HCID 67417518(s)-3-Amino-but-2-enoic acid [1-(4-methoxy-phenyl)-ethyl]-amide

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
100 °C

실험 절차

To a suspension of (S)—N-[1-(4-methoxy-phenyl)-ethyl]-3-oxo-butyramide (10 g) in toluene (800 ml) was added at 20° C. ammonium acetate (10 g) and the reaction was heated for 20 h at 100° C. in a Dean Stark system. The mixture was concentrated in vacuo and the product obtained was used without further purification in the following reaction step.

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe product obtained
  3. customwas used without further purification in the following reaction step

출처 및 근거

ORD 기록
ord-604860e08133494c8cb94413d7eda6e1
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022218B2

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