Hydrochloric Acid → HCID 178431958, 화합물

반응식

C([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[S:17][CH:18]=[C:19]([CH3:21])[N:20]=2)[CH:10]=1)C1C=CC=CC=1.Cl>>[CH3:21][C:19]1[N:20]=[C:16]([NH:15][C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][N:12]=2)[S:17][CH:18]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 866347144-(benzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine

생성물 1

HCID 178431958HCID 178431958, 화합물수율 38.7%

실험 절차

Following the method of Example 3, Step A, 4-(benzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine (prepared according to Example 17) (2.3 g, 7.73 mmol), and HCl (38.7 mL, 116 mmol) (3M HCl) were reacted to provide 2-(4-methylthiazol-2-ylamino)pyridin-4-ol (0.620 g, 38.7% yield) as white solid. 1H NMR (CDCl3) δ 7.38 (bs, 1H), 6.23 (m, 2H), 6.10 (bs, 1H), 2.28 (s, 3H). HPLC (5 to 95) Rt=1.82 min; Mass spectrum (esi) m/z=208 (M+H).

후처리

customwere reacted

출처 및 근거

ORD 기록: ord-f5a011ecc1e64efb878d0c77616b852f
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08022222B2

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