Sodium hydride → 4-(3-(Tert-butyldimethylsilyloxy)phenylthio)-2-chloropyridine

HRID 910915노트

반응식

HRID 910915 반응식
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([SH:15])[CH:12]=[CH:13][CH:14]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[H-].[Na+].[Cl:18][C:19]1[CH:24]=[C:23]([N+]([O-])=O)[CH:22]=[CH:21][N:20]=1>>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([S:15][C:23]2[CH:22]=[CH:21][N:20]=[C:19]([Cl:18])[CH:24]=2)[CH:12]=[CH:13][CH:14]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 24758Sodium hydrideHCID 7351522-Chloro-4-nitropyridineHCID 219768683-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]benzenethiol

생성물 1

HCID 866347184-(3-(Tert-butyldimethylsilyloxy)phenylthio)-2-chloropyridine수율 64.4%

실험 절차

Using the method of Example 3, Step A, 3-(tert-butyldimethylsilyloxy)benzenethiol (1.52 g, 6.31 mmol), 60% sodium hydride in mineral oil (252 mg, 6.31 mmol), and 2-chloro-4-nitropyridine (1.00 g, 6.31 mmol) were reacted to provide 4-(3-(tert-butyldimethylsilyloxy)phenylthio)-2-chloropyridine (1.43 g, 64% yield) as an oil. 1H NMR (CDCl3) δ 8.11 (d, 1H), 7.34 (t, 1H), 7.16 (d, 1H) 7.02 (s, 1H), 6.97 (d, 1H), 6.90 (s, 1H), 6.87 (d, 1H).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-cdf14439d4644a04a7b5390ee2f77589
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022222B2

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