2-Acetyl-5-methylthiophene → 1-(5-Methyl-2-thienyl)ethanol

HRID 911348

반응식

HRID 911348 반응식
[BH4-].[Na+].[C:3]([C:6]1[S:7][C:8]([CH3:11])=[CH:9][CH:10]=1)(=[O:5])[CH3:4]>CO>[OH:5][CH:3]([C:6]1[S:7][C:8]([CH3:11])=[CH:9][CH:10]=1)[CH3:4]

참가 물질

4

반응물 2

HCID 836552-Acetyl-5-methylthiopheneHCID 4311764Sodium borohydride

생성물 1

HCID 150917951-(5-Methyl-2-thienyl)ethanol수율 98.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Add sodium borohydride (270 mg, 7.13 mmol) to a solution of 2-acetyl-5-methylthiophene (1.0 g, 7.13 mmol) in methanol (40 mL). Stir the mixture for 1 h at room temperature. Remove the solvent in vacuo and partition the residue between water and DCM. Separate the organic phase, dry over Na2SO4, filter and concentrate to obtain the desired intermediate as an oil (0.995 g, 98%) that was used without further purification. GC-MS m/z 142 (M+).

후처리

  1. customRemove the solvent in vacuo
  2. custompartition the residue between water and DCM
  3. customSeparate the organic phase
  4. dry with materialdry over Na2SO4
  5. filtrationfilter
  6. concentrationconcentrate

출처 및 근거

ORD 기록
ord-35e11b1c7cc242e69b94091dbc8564d5
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022062B2

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