Diethyl Ether → 1-(6-Methylpyridin-2-yl)ethanol

HRID 911432

반응식

HRID 911432 반응식
[CH3:1][C:2]1[N:7]=[C:6]([CH:8]=[O:9])[CH:5]=[CH:4][CH:3]=1.[CH3:10][Mg]Br.CCOCC>C1COCC1>[OH:9][CH:8]([C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=1)[CH3:10]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 707376-Methyl-2-pyridinecarboxaldehydeHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 3531381-(6-Methylpyridin-2-yl)ethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 6-methylpyridine-2-carboxaldehyde (2.0 g, 16.5 mmol) in dry THF (55 mL) at 0° C. under nitrogen, add a solution of 3M methyl magnesium bromide in ether (6.0 mL, 18.0 mmol) dropwise with stirring. After 1 h at 0° C., quench with saturated aqueous NH4Cl, extract three times with EtOAc, dry over anhydrous Na2SO4 and concentrate in vacuo to give the desired intermediate (crude, 2.3 g).

후처리

  1. customquench with saturated aqueous NH4Cl
  2. extractionextract three times with EtOAc
  3. dry with materialdry over anhydrous Na2SO4
  4. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-e4e089cff6174624942de9363c4cc38b
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022062B2

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