4-(Chloromethyl)phenyl acetate → HCID 57656056, 화합물

HRID 911521

반응식

HRID 911521 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:26]([O:29][C:30]1[CH:35]=[CH:34][C:33](CCl)=[CH:32][CH:31]=1)(=[O:28])[CH3:27]>>[C:26]([O:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:21][S:20][C:15]2[C:12]3[CH2:13][CH2:14][N:8]([C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH2:9][CH2:10][C:11]=3[CH:18]=[CH:17][C:16]=2[Cl:19])=[CH:32][CH:31]=1)(=[O:28])[CH3:27]

참가 물질

3

반응물 2

HCID 1483124-(Chloromethyl)phenyl acetateHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

생성물 1

HCID 57656056HCID 57656056, 화합물

실험 절차

Use a method similar to the Preparation 177, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 4-(chloromethyl)phenyl acetate to give 6-(4-acetoxybenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine as a white solid.

후처리

  1. customsimilar to the Preparation 177

출처 및 근거

ORD 기록
ord-897100b63ff64991a19ac421ecb45a9b
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022062B2

연결된 노트

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